Manchester United pair, Phil Jones and Danny Welbeck will be the only certainties not to feature in what will be David Moyes' first Champions League match as manager.
The English pair both missed training on Monday and will play no part in the match at Old Trafford. Wayne Rooney will once again wear his protective headband, whilst Shinji Kagawa could feature as he starts to recover from illness.
Leverkusen boss Sami Hyypia will be sweating before the game as he could be missing key midfielder Lars Bender, who will face a late fitness test. The German international missed his sides 3-1 win over the weekend and is a doubt for the match.
Manchester United manager David Moyes is excited for his first taste of Champions League football as his side take on Bayer Leverkusen on Tuesday evening. This will be a new experience for the ex-Everton manager and he can't wait to get going.
Speaking to the press on Monday evening, he said: "I'm really excited about it. I've been excited ever since I joined United. Every game has offered a new challenge and a tough one as well. I've been there before with Everton – we didn't quite make the group stages but this is different. This is a club that's used to getting to the latter stages."
Moyes is also wary that Group A will be a tough challenge for his United side as he reflected on his group with Ukrainian champions, Shakhtar Donetsk, Spanish side Real Sociedad and Bayer Leverkusen: "You used to be able to always pick out the group winners but in the last few years that has become more difficult.
"It is more unpredictable than it was. We've got a leading team from Germany, one from Spain and we go to Donetsk to play Shakhtar. It's a tough group."
Like Moyes, Bayer Leverkusen manager and ex-Liverpool captain, Sami Hyypia will be making his Champions League debut and he hopes his side don't get star struck once they arrive at Old Trafford:
"I hope my players want to play football in Manchester and not just get autographs from Rooney," said Hyypia in his pre-match press conference.
Last season, Hyypia managed to lead his team to third in the Bundesliga, a point behind Borussia Dortmund to seal their place in the Champions League. His side are currently third in the Bundesliga, behind Bayern Munich and Borussia Dortmund with four wins out of five games.
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