The city of Manchester will come to a standstill on Sunday afternoon as City and United meet at the Etihad Stadium for the first derby of the season.
Always a fiery occasion, clashes between the two sides have become even more significant over the past few years with the emergence of the Sky Blues as a genuine title threat.
It was the red half of the city that rejoiced at the end of last season when the Premier League trophy returning to Old Trafford after a year at Eastlands.
And there is no doubt that the outcome of Sunday's match will bear significance on the way the table looks when May comes around.
However the Manchester derby has not always been a top of the table clash. For a period in the 1990s they were few and far between as City languished in the lower leagues while United dominated the Premier League.
Even so, whenever these two clubs have met down the years the matches have thrown up all sorts of action, from broken legs to astonishing goals.
Here GMS takes a look at some of the most memorable moments from the Manchester derby down the years.