The tie of the round sees Liverpool travel to Manchester United, both sides off the back of disappointing defeats.
While Brendan Rodgers will be upset at losing Liverpool’s unbeaten start to the season and the nature of Liverpool’s performance in their one-nil loss to Southampton at Anfield, David Moyes has more worries after his side was simply outplayed in the Manchester derby.
The Eeds have already overcome United this season, although that game was not at Old Trafford like this one, but Rodgers can welcome back Luis Suarez for his first club appearance of the season after his ban for biting Branislav Ivanovic last season. With Liverpool lacking creativity against the Saints, the Uruguayan could prove vital.
Moyes on the other hand may be able to call on Robin van Persie, but after his side’s 4-1 loss at City the problems are clearly not just in attack.
The midfield was overpowered by City and the likes of Tom Cleverley, Nani, and perhaps Anderson could make an appearance. However, given that they are neither good enough to start for United nor no longer young promising prospects, the team Moyes sends out on Wednesday will not trouble Rodgers too much.
The defeat against Saints put a dampener on the red half of Merseyside, who to be honest were lucky to start the season so well.
A saved penalty in their opener against Stoke started a run of three single goal wins, while Jonjo Shelvey provided his club with a couple of assists in the draw at Swansea.
A shot at the title was always a touch ambitious, but Liverpool can challenge for a top four spot, but even if they miss out on the Champions League it is no disaster.
An early cup win could convince Rodgers’ superiors to continue funding his rebuild and would no doubt soften the blow if their top four aspirations were not met.