And Spurs boss Andre Villas-Boas should welcome back a number of first-team stars rested in the 4-0 victory over Aston Villa in the Capital One Cup in mid-week.
The likes of Roberto Soldado, Christian Eriksen and Hugo Lloris should return, while Aaron Lennon faces a late fitness test on a foot injury.
Danny Rose is also available, according to the BBC, and is likely to start at left-back.
Spurs, currently second in the Premier League, have the best defensive record in Europe so far this season, conceding just one goal. So, against a Jose Mourinho team, expect a low scoring match.
While they're stingy at the back, they're free-flowing gong forward. Tottenham average the most shots per game in the Premier League - largely thanks to the shoot-on-sight policy favoured by Andros Townsend.
The young winger, who recently received an England call-up, averages 5.5 shots per match - the highest in the Premier League.
But with Erik Lamela reaching full fitness, Townsend may have to settle for a place on the bench.
With that in mind, here's the GMS predicted starting lineup for the match against Mourinho's Chelsea…
Lloris, Walker, Dawson, Vertonghen, Rose, Paulinho, Dembele, Chali, Lamela, Eriksen, Soldado
What do you think? Have your say on who you think will start below...