Manchester United go into their Champions League showdown against Shakhtar Donetsk tomorrow without Rio Ferdinand, who misses the game with a groin strain.
Anderson and Wilfried Zahai are also absent, while manager David Moyes has confirmed that Robin van Persie is fit to take part having overcome injury.
Nemanja Vidic and Patrice Evra should return having been rested for the 2-1 defeat against West Brom over the weekend.
The Manchester United boss is confident he can pick up a result at the Donbass Arena on Wednesday.
“I think we need to go there with a strong team. Going to Ukraine is tough because Donetsk have had a good record," he told reporters.
“I know they’ve sold one or two players but they have five or six Brazilians; they are not all Ukraine-based players but from all over the place.
“Bayer Leverkusen was fantastic and I’m really looking forward to Wednesday and seeing what it’s like getting to be involved in these competitions.
Both Manchester United and Shakhtar for their campaigns up and running with wins last month, and will battle it out for supremacy in Group A tomorrow night.
For Moyes the game represents his first chance to take charge in an away Champions League tie, and he is under no illusions how difficult it is to win anywhere in Europe.
“I think the history here is to be known throughout Europe; Manchester United and their history shows you that has been the case," he said.
“It has become a harder competition to win with the spending power of some of the big teams in other countries
“With the emergence of all the good Spanish players and Spanish teams and now you have PSG… the competition has become much more open than it was in years gone by.
“It’s been hard for Manchester United as well and progress is not something that is guaranteed.
“There were no guarantees for Manchester City last year. You have to play well enough and grow into it and, hopefully, keep moving along.”