Manchester United, Arsenal and Manchester City have been placed on red alert after Napoli rejected the chance to take Valencia defender Adil Rami on loan in January, reports the Daily Star.
The 27-year-old France international has been the subject of intense transfer speculation ever since he was made available last week, following critical comments he directed at the Spanish club's board.
Rami is currently serving a 10-day suspension after questioning the summer sales of Roberto Soldado and Alberto Costa, and is now free to leave the Mestalla when the transfer window reopens.
Valencia president Amadeo Salvo wants to offload the centre-back on an initial loan deal in the New Year, in an attempt to rid Miroslav Dukic's dressing room of any disruptive influence.
But, after offering Rami to former Valencia boss Rafa Benitez - now in charge of Serie 'A' side Napoli - Salvo has seen his loan proposal turned down, and so will look to alternative suitors for the wantaway star's signature.
Gunners boss Arsene Wenger has been credited with an interest in bringing Rami to the Emirates Stadium, as he looks to further strengthen his defensive line in north London.
Manchester United manager David Moyes is also believed to be monitoring the player's situation, as he too weighs up a bid to lure him to Old Trafford.
Meanwhile, Manuel Pellegrini completes the trio of interested Premier League coaches reportedly keen on recruiting Rami, with Manchester City suffering from a spate of injuries that has stretched their defence during the early part of the 2013/14 campaign.
All three clubs were keen on signing the player during the summer, but none met Valencia's £9million valuation of the defender.
With Rami set to return to first-team training on Monday, it remains to be seen whether he will return to Dukic's first-team fold. But, failure to do so will certainly prompt Manchester United, Arsenal and Manchester City to each make cut-price offers to sign him permanently after the loan spell at the end of the season.