It's the final round of Premier League fixtures before the last batch of 2014 World Cup qualifiers, and while Arsenal attempt to hold onto top spot, reigning champions Manchester United have their sights set on moving into the top half of the table.
The rest of the 18 clubs are also in action over the course of Saturday and Sunday - and here's how we think the 10 matches will pan out.
Manchester City 2 - 0 Everton
Manchester City were outclassed by Bayern Munich in midweek but will be keen to make amends against the in-form Everton.
The Toffees are playing some excellent football right now, but they could come unstuck at the Etihad Stadium.
Cardiff City 1 - 1 Newcastle United
Newcastle United were blown away by Everton in the first half on Monday night - and now face a difficult trip to Cardiff City.
The Bluebirds are a decent side, particularly at home, but this one should end all square.
Fulham 0 - 0 Stoke City
Fulham have scored four goals this season, so have Stoke. Therefore, don't expect this one to be a classic.
Hull City 1 - 2 Aston Villa
Aston Villa have already picked up some superb results this season and could rise as high as fifth place with victory away at Hull City, who have exceeded expectations at the start of this season but could find themselves outclassed by Paul Lambert's men.
Liverpool 3 - 0 Crystal Palace
If you want goals this weekend, look no further than Anfield, where Liverpool should batter Crystal Palace.
Luis Suarez is back and scoring, Daniel Sturridge is on fire, while Palace have lost five of their opening six matches.
Sunderland 1 - 2 Manchester United
A huge game for Manchester United, who simply must beat rock-bottom Sunderland on Saturday evening.
The Red Devils are currently 12th in the Premier League table after last weekend's home defeat to West Brom, but can fire themselves back up the table with three points at the Stadium of Light.
Norwich City 1 - 3 Chelsea
Chelsea recorded a fine away win in the Champions League this week and should follow that up with victory at Carrow Road on Sunday afternoon.
Southampton 2 - 1 Swansea City
Southampton have won their last two matches and this weekend take on a Swansea City side who were involved in Europa League action on Thursday evening.
The Swans may be feeling the effects of their busy schedule, so expect Saints to secure maximum points in this one.
Tottenham 3 - 0 West Ham
Tottenham are currently flying high and should comfortably beat a West Ham side who have failed to win since the opening day of the season.
West Brom 1 - 2 Arsenal
A big test for Arsenal. Are they genuine title contenders or merely pretenders?
West Brom will be riding the crest of the wave following last weekend's famous win at Old Trafford, but the Gunners look unstoppable right now.