The young striker was performing well for the South Yorkshire club before injury struck and Donny manager Paul Dickov is trying to revive the deal once he's fit.
Macheda was impressing in the Championship, netting three goals in five appearances.
Though the Italian is expected to be out for a while, the second-tier club are hoping they will be able to complete a deal before the emergency loan deadline on November 28.
And Dickov confirmed that the club are trying to get a deal done for the 22-year-old.
"First and foremost, we were all disappointed because he made an immediate impact and we felt with the more games he was going to get, the better he was going to be," he said to the Yorkshire Post.
"But there's been contact between the clubs and I know Gavin (Baldwin - chief executive) has spoken to his counterpart over at Manchester United and the possibility of getting him back.
"He's going to be out for a few weeks, so it gives us some time to let us do it."
Macheda has struggled to live up to early hype since he scored a stunning winner as a 17-year-old debutant against Aston Villa.
The Italian has since failed to display the sort of quality that his early promise suggested.
Were he to stay at United, he would unlikely get much game time.
As it is, fourth-choice striker Hernandez is reportedly looking for a January move, with a lack of playing time inevitably going to affect his World Cup position with Mexico.