Manchester United would appear to have a number of injury doubts ahead of Wednesday's Champions League clash against Real Sociedad, with Sky Sports reporting that the key quartet of Rio Ferdinand, Nemanja Vidic, Danny Welbeck and Tom Cleverley all missed training on Tuesday.
United go into the fixture against La Liga opponents with new manager David Moyes having been placed under considerable pressure after largely failing to secure a number of high-profile transfer targets during the summer and additionally presiding over a notably poor start to the new domestic campaign.
Despite their Premier League woes, however, Moyes' side have enjoyed a solid start to their European campaign and currently top Group A after collecting four points from their opening two fixtures at home to Bayer Leverkusen and away to Ukrainian champions Shakhtar Donetsk.
Many are subsequently expecting them to record a relatively straightforward victory over their Spanish counterparts, with Jagoba Arrasate's side currently sitting bottom of the group having suffered consecutive defeats.
That task may be made more difficult, however, with the news that such an important quartet were unfortunately absent from training ahead of the match.
The trio of Ferdinand, Vidic and Cleverley all missed United's disappointing 1-1 draw with Mauricio Pochettino's Southampton at Old Trafford on Saturday while Welbeck was restricted to a brief cameo appearance after replacing combative midfielder Marouane Fellaini with 15 minutes remaining.
Doubts will now inevitably surround the quartet with the news that they did not take part in training.
One positive piece of news for Red Devils fans, however, is that Belgian-born starlet Adnan Januzaj - who endeared himself to the United faithful with a stunning brace to secure victory over struggling Sunderland at the Stadium of Light prior to the recent international break - trained after being recent added to Moyes' Champions League squad.