The Gunners have a long history under Arsene Wenger for using the League Cup to ease young players into the first team, and that doesn't appear likely to change tomorrow.
With a number of big games approaching Wenger is expected to juggle his squad, and he intends to use several young players in padding out his squad.
When asked what youngsters Arsenal fans could expect, Wenger said: "Isaac Hayden will be involved, Ryo and [Serge] Gnabry if he's fit."
Gnabry was a first half substitute in Arsenal's victory over Crystal Palace, replacing the injured Mathieu Flamini.
The young German won the penalty for Arsenal, before being replaced late on following Mikel Arteta's red card.
And it appears, along with Flamini, Gnabry may be a casualty of the 2-0 win.
"Serge Gnabry has a problem, he got a kick on the ankle." said Wenger on Arsenal.com. "He will be assessed tomorrow. After that we will decide who plays and who doesn't play."
On Flamini Wenger said: "He has a scan today and then we will get the results as to how long he will be out.
"It doesn't look like a bad muscle injury but honestly it's too early to give you a precise answer. It's a groin injury," he said.
The loss of Flamini is a blow to Arsenal, with the Frenchman proving vital to Arsenal since his summer switch on a free.
The blow is worsened by the fact that Mikel Arteta is out with a suspension, although the Spaniard only misses the Chelsea clash and should return in time for the Gunners' game against Liverpool.
Another youngster expected to play a part tomorrow was American midfielder Gedion Zalalem.
The 16-year-old was likened to Cesc Fabregas in pre-season, and it was thought the League Cup would present the perfect opportunity to introduce the youngster.
However, Wenger confirmed that the game comes too soon for Zelalem after an injury:
"He is not yet available. He had a knee problem. He is back in full training but he has not played yet. He will play 45 minutes with the under-18 team later this week."
The game represents the first fixture between Arsene Wenger and Jose Mourinho since the Portuguese left Chelsea in 2007.