Boston Red Sox tied the World Series at 2-2 after defeating the St Louis Cardinals 4-2.
Jonny Gomes, who was only on the field to replace the injured Shane Victorino, hit a three-run homer off the Cardinals relief pitcher Seth Maness in the sixth innings, guaranteeing the Series will run to at least six games.
The Red Sox went in to the game at the Busch Stadium on the back of successive losses.
Both of those defeats were littered with glaring mistakes in the field and it was with a similar mistake from Jacoby Ellsbury that gifted the Cardinals the first run of the game in the third innings.
Stephen Drew tied the game for the Red Sox in the fifth innings before Gomes hit the game winning shot in the sixth innings to give the Boston based franchise a 4-1 lead.
The lead silenced a record crowd in St Louis and proved unassailable.
Matt Carpenter managed to reduce the lead in the seventh, making it 4-2 when his single allowed Shane Robinson to get home.
The relief pitching of John Lackey and the closing of Koji Uehara saw out the game for the Red Sox.
David Ortiz, who was seen rallying the Red Sox in the dugout throughout the game, told reporters: "You think you're going to come to the World Series every year, you're wrong.
"I told them, 'It took me five years to get back on this stage, and we had better teams than what we have right now, and we never made it. Take advantage of being here'."
The fifth game will be played on Monday at the Busch Stadium before returning for the sixth and a seventh - if required - at Fenway Park.