Andre Villas-Boas will see the duo's return as a timely boost for his squad, as Spurs face Hull at White Hart Lane for the second time in four days.
After an unconvincing performance in Sunday's fixture - which led to Villas-Boas bizarrely criticising fans for his side's lacklustre performance - Capoue and Kaboul's return will be a welcome sight.
Summer signing Capoue has started just two league games for the club since his £9million switch this summer.
The Frenchman was injured in Spurs' derby defeat to Arsenal in September, but has recently resumed training.
Kaboul, meanwhile, hasn't started a game in the Premier League since the opening day of last season.
The former Portsmouth defender suffered a serious injury but his return to training puts him in contention for the fourth round tie on Wednesday.
It is believed Villas-Boas will use the cup game to build up the pair's fitness ahead of their Premier League game with Everton at the weekend.