Olivier Giroud is struggling to shake off a knee injury ahead of the crunch tie against Manchester United on Sunday, reports Goal.com.
The Arsenal striker has been a key part of Arsenal's early-season success so far, scoring five goals and creating four in the Premier League.
Thanks to a lack of alternative options, Giroud has started a total of 16 games so far for Arsenal this season - more than any other outfield player.
And it seems that fatigue may be starting to set in at the wrong time as Giroud is struggling to recover from a knee injury sustained in the 1-0 win against Borussia Dortmund.
Although facing a fitness test ahead of the crucial tie against Manchester United at Old Trafford on Sunday, Giroud is believed to be confident of recovering in time to start against David Moyes' men.
If Giroud is unavailable it would be a massive blow for Arsene Wenger, who has just Nicklas Bendtner and Chu Young-Park to call on in reserve.
Together they have made less than five starts for the club in over two years after being shipped out on loan last year after being deemed surplus to requirements.
It is not all doom and gloom for Arsenal, however, as Mathieu Flamini is reportedly set to return following a two week absence.
Theo Walcott and Jack Wilshere also have a small chance of being fit to face the Red Devils but face uphill battles to recover from their respective injuries.
The latter has been called up to the England squad for next week's friendlies against Chile and Germany, increasing speculation that he will be fit for Sunday.