Barcelona midfielder Cesc Fabregas has been ruled out of Spain's squad for their upcoming fixtures after he suffered a knee injury during his sides 4-1 thrashing of Real Betis at the weekend.
The former-Arsenal man is out of action for a week after spraining ligaments in his right knee on Sunday, the Catalan club confirmed on their official website.
He's been replaced by club team-mate Marc Bartra, who could earn his first cap for the World and European champions when they face Equatorial Guinea on November 16, or against South Africa three days later.
Fabregas told their official website after Sunday's game: "I wasn't comfortable, and seeing that the match was beyond Betis' reach I preferred to be substituted."
The 26-year-old, a product of Barcelona's famous La Masia academy before he moved to Arsenal, underwent tests on Monday which confirmed the sprain.
It allows Vincente del Bosque to call up Bartra for the first time, after the centre-back impressed in the 2013 U21 European Championships - which Spain won. He also featured during their successful 2011 tournament.
In total, he has made 16 appearances for the Under-21s - and the 22-year-old could make his first start for Spain's senior team on Saturday in Malabo or next Tuesday in Johannesburg.
The former RCD Espanyol youngster joined La Masia when he was only 11-years-old, eventually forcing his way into Pep Guardiola's first team in 2009/10 when he made his debut against Atletico Madrid.
He joins Barcelona team-mates Victor Valdes, Sergio Busquets, Andres Iniesta and Pedro in Del Bosque's squad.
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