Portuguese newspaper A Bola claims that the Chelsea trio could be sold to fund a major spending spree in the winter window.
The report suggests Mourinho has targeted three top targets - two strikers and a central defender - although he'd have to sell to at least partially fund the incomings.
And Luiz, Ba and De Bruyne are three Blues players who reportedly face uncertain futures.
De Bruyne began the season in Mourinho's starting lineup after a successful season on loan with Werder Bremen.
But he quickly dropped out of the team, and attracted the ire of the Chelsea boss for his lacklustre performances in training and against Swindon in the Capital One Cup.
He has since been linked with a move to Anderlecht in the January transfer window, with competition for places at Chelsea - especially in the Belgian's attacking midfield position - fierce.
David Luiz was similarly dropped after the 2-0 defeat to Newcastle, and has not featured since in matches against West Brom and Schalke.
Gary Cahill has stepped in to partner John Terry in the heart of the Chelsea defence.
And Demba Ba has never been first-choice under Mourinho, prompting speculation the former-Newcastle man could be one of the first out the exit door come January.
There's thought to be plenty of interest in the forward, with Arsenal the latest to be linked with the Senegal international.