Manchester United duo Michael Carrick and Danny Welbeck have withdrawn from the England squad ahead of the forthcoming friendlies against Chile and Germany.
Welbeck missed Sunday's 1-0 win over Arsenal with a knee injury, while Carrick played the whole 90 minutes but left Old Trafford with a slight Achilles problem.
"I have been carrying the injury for a few weeks now," he told reporters at the weekend. "I was a bit patched up to play. I got through it but it doesn't look too good."
England take on Chile on Friday night at Wembley Stadium, before taking on old foes Germany at the same venue on Tuesday evening.
In Carrick's absence, England boss Roy Hodgson may take the chance to give the likes of Ross Barkley, Jordan Henderson or Adam Lallana a chance to impress.
The trio were part of a 28-man squad called up by Hodgson last Thursday, which also included Southampton's uncapped striker Jay Rodriguez.
Carrick and Welbeck become the second and third Manchester United players to withdraw from an international squad today, following the news that Robin van Persie will not play in the Netherlands' friendly fixtures against Japan and Colombia because of toe and groin injuries.