With both Manchester teams looking to banish memories of poor starts to the new campaign and re-assert themselves in the title race, here we pick an XI made up of players from the respective rivals...
Goalkeeper - David de Gea
A year ago, Joe Hart would have had this position nailed on. Howeverm while his form has dipped, De Gea has just got better and better. United's number one is now one of the finest shot-stoppers in the league.
Right-back - Pablo Zabaleta
Zabaleta is Mr. Consistency and never puts in a bad display. United seem to be chopping and changing at right-back between Chris Smalling and Rafael. Neither of those two are as good as Zabaleta yet.
Centre-back - Vincent Kompany
Kompany leads by example and provides a cool head in the heart of City's defence. When Kompany is injured, City look far weaker defensively and concede more goals.
Centre-back - Nemanja Vidic
A fully fit Vidic is as good a centre-half as there is out there. As he demonstrated against Arsenal, he is not afraid to put his head where it hursts for the good of the team and his bravery is exemplary.
Left-back - Patrice Evra
Evra has consistently been one of the best left-backs in the Premier League ever year since 2007. There is not a lot between he and Gael Clichy, but his leadership makes him slightly more influential on the field.
Right-midfield - Jesus Navas
Since his arrival from Sevilla in the summer, he hasn't had things all his own way. However, what Navas does have is undeniable pace and ability. He drifts past proven left-backs like they aren't even there and always poses a threat.
Centre-midfield - Michael Carrick
There is no-one better at protecting the back four in England than Carrick. His positioning and ball distribution is first class and United just don't look the same team without him.
Centre-midfield - Yaya Toure
The Ivorian midfield powerhouse is in scintillating form at the moment. He often single-handedly carries City from defence to attack with his strength and dribbling ability and has also proven how deadly he is from set pieces this season.
Left-midfield - David Silva
Spanish international Silva shows moments of genius with the ball at his feet. He picks the right pass time and time again and provides Sergio Aguero and Alvaro Negredo with superb through balls when the opposition least expect it.
Striker - Wayne Rooney
Rooney has shown just how valuable he is to United in the opening eleven Premier League games this season. A great work rate and deadly finishing are just two of a long list of attributes he possesses.
Striker - Robin van Persie
This is extremely harsh on Aguero, but RVP is just too good to leave out. His lethal finishing and movement in and around the eighteen-yard box is arguably as good as anyone in world football.
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