The 20-year-old striker could join fellow-United youngster Nick Powell at the DW Stadium after Wigan boss Owen Coyle admitted he was close to agreeing a deal for an "exciting young player".
The report claims United's Will Keane is the player in question. His brother Michael Keane, who is also on the books at United, spent time on loan at Leicester City last season.
After an injured ravaged 16 months, United hope Will gets the opportunity to play first-team football in the Championship.
He made his Premier League debut for United in December 2011, but is yet to appear again for the Red Devils.
The England-under 21 international could partner Powell up front for the Latics, with Coyle struggling with a string of injuries to his first-choice strikers.
Grant Holt and Marc-Antoine Fortune are both sidelined, with Powell deployed as an auxiliary forward.
And Coyle has seemingly opted to return to Old Trafford to supplement his attacking options, with Keane his preferred option.
He told the Wigan Evening Post: "It's a young player who is an exciting player, a striker who I've watched for a number of years and I'm a huge admirer of.
"It will certainly add to the squad, we want to make sure that we have a squad that will cope with the demands of the set of fixtures that are in front of us."