Liverpool can climb to the summit of the Premier League table tomorrow afternoon before Arsenal even play, with Brendan Rodgers' side facing Everton in the weekend's early kick-off.
Three points at Goodison Park will propel the Reds one point clear of the Gunners and mean the north London club need a positive result against Southampton to have any hope of reclaiming the lead.
Liverpool's hopes of victory in the Merseyside derby will be boosted by the news that Kolo Toure is available for selection again, and the Ivorian centre-back is likely to slot back into Rodgers' defence.
Rodgers favoured 4-4-2 in Liverpool's last outing - a 4-0 win over Fulham at Anfield - and may opt for this formation against the Toffees given that the game will surely be one or lost in the midfield.
This will mean two central defenders rather than the three that have been utilised often in recent weeks, with Daniel Agger dropping to the bench and Mamadou Sakho afforded a period of rest after his midweek exertions with France.
The return of Toure is the only predicted change from the XI that started the game with Fulham, although Daniel Sturridge may miss out as he has been suffering with a dead leg.
Predicted Liverpool XI to face Everton on Saturday...
Simon Mignolet; Glen Johnson, Martin Skrtel, Kolo Toure, Aly Cissokho; Lucas, Jordan Henderson, Steven Gerrard, Philippe Coutinho; Daniel Sturridge, Luis Suarez.
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