Bayer Leverkusen forward Sidney Sam has been ruled out for up to a month after sustaining a thigh injury.
The in-form 25-year old had to be replaced just four minutes into Leverkusen's 1-0 away win against Hertha Berlin on Saturday.
Sami Hyypia's team picked up their 10th win in 13 league games in Sam's absence following a first-half strike by German international Stefan Kiessling.
The victory - which saw Leverkusen leapfrog Borussia Dortmund to move into second place behind league leaders Bayern Munich - was dampened after Sam hobbled off clutching his left thigh.
The German international was originally only ruled out of Wednesday's key Champions League clash against Manchester United, but further scans today revealed that the injury is more serious than expected.
"His absence is very bad news for us," Leverkusen sports director Rudi Voller was quoted by Sky Sports.
"This is the game of games for us in the Champions League so we have to put everything we have in it without Sam."
The BayArena based side currently lie in second place behind Manchester United in Group A but have the chance to leapfrog David Moyes' side with a win in front of an expectant home crowd.
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