Manchester United can secure qualification for the 2013/14 Champions League knockout stages by beating Bayer Leverkusen on Wednesday evening.
But the Red Devils must lift their spirits and bounce back from Sunday's disappointing 2-2 draw against Cardiff City.
David Moyes' men were on course to seal three much-needed Premier League points, which would have been enough to see them jump into the top four, but they shot themselves in the foot by conceding a stoppage-time equaliser from a set-piece.
United will be keen to avoid such complacency on Wednesday. The Red Devils will want to finish the job this week, rather than relying on their final group stage match against the tricky Shakhtar Donetsk in a fortnights' time.
Moyes is expected to make a few changes from the team which drew 2-2 at the weekend.
Nemanja Vidic could potentially return to the starting line-up after missing the Cardiff clash, while veteran midfielder Ryan Giggs - who celebrates his 40th birthday this week - could come in for the suspended Marouane Fellaini. However, Phil Jones is back in contention after recovering from injury, as is Brazilian right-back Rafael, although both may start on the bench.
Robin van Persie did not train today, so will not feature in Germany, which could pave the way for Javier Hernandez to make another start.
And Adnan Januzaj is expected to make way for either Shinji Kagawa or Danny Welbeck, who turns 23 today.
Manchester United predicted XI v Bayer Leverkusen
Goalkeeper: David de Gea
Right-back: Chris Smalling
Centre-back: Nemanja Vidic
Centre-back: Jonny Evans
Left-back: Patrice Evra
Central-midfielder: Tom Cleverley
Central-midfielder: Ryan Giggs
Right-wing: Antonio Valencia
Attacking-midfielder: Wayne Rooney
Left-wing: Danny Welbeck
Striker: Javier Hernandez