Manchester United David Moyes boss is reportedly considering a January swoop for either Angel Di Maria or Koke, after previous La Liga target Ander Herrera has expressed his desire to remain in Spain.
Herrera was close to leaving Athletic Bilbao for Old Trafford last summer, but a deadline-day deal fell through.
As a result, United are expected to be busy in the transfer market with the club readying bids for Di Maria and Koke.
In a bid to add fresh creativity to the United attack, the Argentinian winger has been identified as his main target.
According to the Daily Mirror, the ex-Everton boss is considering meeting Di Maria's release clause in a bid to prise him away from the Bernabeu.
Moyes had hoped to seal a double deal for Di Maria and his Madrid team-mate Sami Khedira, but the latter received a serious knee injury while on Germany duty which has ruled out any chance of a transfer in January.
The arrival of world-record signing Gareth Bale to the Bernabeu has seen Carlo Ancelotti's need for Di Maria lessen, although the 25-year-old is still a stunning player and would light up the Premier League his pace and skill.
United are eager to secure their top target after a disappointing time in the previous transfer market, missing out on the likes of Cesc Fabregas, Wesley Sneijder and Thiago Alcantara in the summer.
In the other half of Madrid, Koke has become one of the hottest properties in Europe after a sensational start to season playing a key role in Atletico's climb to second place in La Liga, ahead of rivals Real Madrid.
The 21-year-old's performances have been noted by United, who are ready to launch £16m bids to activate his release clause.
Atletico boss Diego Simeone is desperate to keep hold of the Spaniard as he looks to sustain their stunning form and mount a title challenge to Barcelona who are currently top of their league.
The United boss may allow Brazilian international Anderson to leave Old Trafford in the new year to pave the way for Koke, who he has chosen to be the one to add the creative flair to his midfield following the retirement of Paul Scholes.
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