Liverpool striker Daniel Sturridge has been ruled out for six to eight weeks with an ankle injury.
The 24-year old, who has impressed for both club and country so far this season, picked up the knock in training this week which is likely to keep him out of action until late January.
Manager Brendan Rogers confirmed the news to Sky Sports and he said: "Daniel Sturridge is out for six to eight weeks, which is obviously a big blow.
"It was something we thought was never going to be as serious as that to be honest.
"He slipped over in training and we thought initially it was his toe. He got brought inside straight away and he was taken for a scan straight away and it showed he'd actually got a ligament strain."
Sturridge was struggling for fitness over the recent international break and this news will no doubt worry both Rogers and England manager Roy Hodgson.
He has been an integral part of Liverpool's start to the campaign, and he has scored 11 goals in his last 14 games for the club, including the equaliser in last weekend's pulsating 3-3 draw with Everton.
Sturridge has also forged an excellent partnership with fellow striker Luis Suarez, but Rogers believes this may give others a chance to impress.
"Raheem Sterling is a terrific player and Victor Moses is very talented. They are both hungry to do well, " he said.