Arsenal face arguably their toughest challenge of the season so far as they take on in-form Manchester City at the Etihad.
Although failing to impress away from home, the Citizens have maintained a 100 per cent record at home, averaging over four goals a game in the process.
But Arsenal themselves have been impressive on their travels, winning five, drawing one and losing one - the best away record in the league this season.
Arsenal also have the best defence in the league, conceding only 11 goals so far. The likes of Per Mertesacker and Laurent Koscielny will need to be at their best to keep out City's formidable strike force.
Sergio Aguero is the current top scorer in the league for City with 12 goals whilst Yaya Toure has contributed seven from midfield and Alvaro Negredo has six.
Manchester City go in to the game on the back of a famous 3-2 victory against Bayern Munich on Tuesday.
Meanwhile, Arsene Wenger saw his Gunners side go down 2-0 to Napoli on Wednesday, giving them a reality check as well as a day less to recover.
Carl Jenkinson is expected to continue in his right-back role after Bacary Sagna failed to recover from a hamstring problem.
For Manchester City their only new injury concern also lies at right-back. Micah Richards picked up a hamstring injury himself in the mid-week 3-2 win at the Allianz Arena and will miss the tie.
The game could see a return to the starting line-up for Theo Walcott, who has been used from the bench since recovering from an abdominal injury last month. Manchester City's high line will be exposed to the forward's pace and Wenger could utilise it from the get-go.
After being rested against Napoli, expect Arsenal's top scorer Aaron Ramsey to return in place of Mikel Arteta, who was sent off midweek in the Champions League.
The game could also see a return for Joe Hart, who has been tipped to start ahead of Costel Pantilimon for the first time in the Premier League since October.
Manchester City predicted XI: Hart; Zabaleta, Kompany, Lescott, Kolarov; Toure, Fernandinho, Navas, Silva; Aguero, Negredo
Arsenal predicted XI: Szczesny; Gibbs, Mertesacker, Koscielny, Jenkinson; Flamini, Ramsey; Cazorla, Ozil, Walcott; Giroud.