Manchester United talisman Robin van Persie is set to miss around eight games after injuring his thigh while taking a corner which led to Phil Jones' goal against Shakhtar Donetsk at Old Trafford.
This is a big blow for the Red Devils who are already missing Patrice Evra, Marouane Fellaini, Chris Smalling and Michael Carrick.
Van Persie's season has been disrupted due to frequent injury.
Against Newcastle, he returned after a one month absence after suffering a groin-injury.
Last season, van Persie was prolific and clinical in front of goal.
He scored 26 goals, and was instrumental in United's efforts to capture their 20th League title.
Without question he will be sorely missed - but this is an opportunity for others to step up.
Shinji Kagawa has been sidelined this season, and has not received sufficient playing time.
He shone against Leverkusen, and will look to grab his chance and impressMoyes.
The Japan international will be able to slot into his favoured number 10 role and work his magic behind target man Wayne Rooney.
Danny Welbeck and Javier Hernandez have thus far been reduced to mostly substitute appearances.
The Mexican forward will be looking to prove his goal-scoring abilities at Old Trafford and force his way into the side.
Danny Welbeck also has a lot to prove after putting in some lacklustre performances.
Wayne Rooney will have to assume the responsibility of scoring and providing goals for his side, both of which he has done admirably this season.
United have had a poor start to their domestic season, and are currently languishing in ninth place.
This injury list will ensure that United have even tougher times ahead, but no one can take a determined and resilient side like Manchester United for granted.
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