Denver Broncos wide receiver Wes Welker will miss Sunday's clash against the Houston Texans after failing to recover from concussion in time, according to Jay Glazer of Fox Sports.
The 32-year-old, who suffered a separate concussion just last month, has not yet received the green light to return to practice.
He missed last week's 27-20 defeat to the San Diego Chargers and will now miss the team's penultimate match of the regular campaign.
There's a chance that Welker could return in time for the game against Oakland Raiders on December 29, but the Broncos may opt to keep him out of action until the play-offs start.
However, Broncos know that victories from their final two fixtures will earn them AFC's top seed, which would subsequently mean a first-round bye.
Andre Caldwell is expected to replace Welker in the line-up this weekend, and Peyton Manning has backed his teammate.
"I thought Bubba Caldwell played really well," he told reporters on Wednesday. "Great route on that first touchdown, did a great job getting in the end zone on a play he hasn't [worked] that much, so that's a good job knowing what to do, being in his playbook. We'll count on him this week if he has to play."