Mauricio Pochettino's first FA Cup action could see him play highly-rated pair James Ward-Prowse and Nathaniel Clyne, with the Daily Mirror reporting that they are fit to face Burnley.
Both England U21 internationals have impressed this season.
The Saints will play host to Championship promotion hopefuls Burnley on Saturday. The Clarets have started their season very well and are currently four points off the top of the table.
Both Danny Ings and Sam Vokes have scored over 10 goals this season, proving a real threat up front.
Southampton have also enjoyed the opening half of the season, with their youngsters playing attractive football and delivering results at the same time.
Jay Rodriguez has been scoring goals of his own in the Premier League, having scored twice away to Cardiff and grabbing the equaliser away to Newcastle last month.
Pochettino will also have the services of club-record signing Dani Osvaldo back with the side after he overcame an illness.
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