The 2012 first round draft pick missed 11 games last term with a herniated disk in his neck.
And while the player hoped to avoid surgery, Giants general manager Jerry Reese told WFAN Radio in New York that Wilson would go under the knife.
The Giants hope to get Wilson back fit and healthy to start next season's campaign, but the report notes the neck area is a particularly vulnerable part of the body for running backs.
The possibility remains that Wilson will be advised to retire from professional football for good, although that depends on the result of the surgery and Wilson's response.
A hugely gifted back, Wilson had problems fumbling the ball before he went down injury, but with Andre Brown set to hit unrestricted free agency this summer, Wilson is potentially a big part of the Giants' future at the position.
Wilson was selected by the Giants with the last pick of the first round in the 2012 draft.
He's rushed for five touchdowns and 504 yards on 115 attempts in his NFL career to date.