Manchester United boss David Moyes is set to show Anderson, Nani and Wilfried Zaha the door this month – although only one of them will be sold on a permanent deal.
The Daily Mail reports that Anderson is set to complete a transfer to Serie A side Fiorentina, while Nani and Zaha will move on loan to Sporting Lisbon and Cardiff City, respectively.
Brazilian midfielder Anderson has failed to cement his place as a first-team regular since arriving at Old Trafford from Porto for £17m in 2007.
The 25-year-old has featured in just four Premier League matches this season and is expected to leave the Red Devils before the winter transfer window closes.
Nani arrived in Manchester at the same time as Anderson and should move back to Sporting Lisbon until the end of the season.
The Portuguese winger, who signed a new five-year deal in September, has struggled with injury this term.
Meanwhile, Zaha has barely featured for the Premier League champions since his £15m transfer from Crystal Palace last January.
The 21-year-old winger, who was sent back to Palace on loan until the end of last season, is likely to join Manchester United legend Ole Gunnar Solskjaer at the Cardiff City Stadium until the summer.