Manchester United take on Cardiff City on Tuesday in a game in which Juan Mata is expected to make his Red Devils debut.
Wayne Rooney, Robin van Persie and Marouane Fellaini could all feature against former Manchester United star Ole Gunnar Solskjaer's Bluebirds after recovering from injury.
The Premier League champions will be hoping they can close the gap on arch-rivals Liverpool, who currently occupy fourth spot.
Manchester United are currently six points off a Champions League spot - having lost seven of their opening 22 league games.
David Moyes is likely to make changes to the side that were knocked out of the Capital One Cup by Premier League strugglers Sunderland.
Patrice Evra and Phil Jones both started on the substitutes' bench last Wednesday but could be reinstated into Manchester United's starting line-up.
Nemanja Vidic will miss tomorrow's game at Old Trafford through suspension while Nani and Michael Carrick remain on the sidelines with hamstring and ankle injuries respectively.
Manchester United predicted line-up: De Gea; Rafael, Smalling, Evans, Evra; Fletcher, Cleverley; Mata, Rooney, Januzaj; Welbeck
Prediction: Manchester United 2-0 Cardiff