The veteran QB knows what it's all about having won the Lombardi Trophy with the Saints three years ago, when his team defeated Peyton Manning's Colts 31-17.
Manning is now with the Broncos and facing off against Seattle, a team Brees has played twice this season, and he feels a turnover-free Denver can prevail in the Super Bowl.
"I tell you what, Seattle's defense is a heck of a defense. The year that they have had has been impressive. We went up there on two occasions this season but unfortunately we didn't make enough plays to win those games," admitted Brees.
"You know what you are going to get when you go up against that defense. They put a lot of pressure on the quarterback.
"It's going to be interesting to see how Denver can manipulate releases. Seattle relies on an offense taking chances and then they punish you by creating turnovers. So if you don't turn the ball over you have a great chance.
"We've tracked Seattle the last couple of years and they have done an amazing job with their draft picks. They have picked up some late rounders and turned them into pro-bowlers.
Any advice for Manning then? "Throw it to the open guy."
Easier said than done.