Drogba will travel with Galatasaray in the Champions League when the pair meet in the first knockout round.
However, despite the Portuguese's excitement, Mourinho remains cautious of the threat Drogba will pose his side.
"I think it will be a special moment for Didier and for the Chelsea fans when he comes back on to the pitch at Stamford Bridge," said Mourinho in the Metro.
"He deserves the best reception – he is a hero here for what he achieved and he is a great guy as well as a great footballer."
The burly Ivorian will go down as an all-time Blues great, but Mourinho will be hoping Drogba doesn't enjoy his return too much.
"There will be a lot of love, but we also have a game to play – we know that Didier will be giving his best because we know the professional he is, but we will also be giving everything to progress," he said.
"For sure, it is going to be something amazing to experience."
Drogba's return to the Bridge will be on the 18th of March, while the first leg takes place in Turkey three weeks earlier.
First up for Mourinho and Chelsea, however, is the visit of struggling Newcastle.
The Magpies will be looking to make up for a disappointing derby defeat, but will come up against a confident Chelsea who defeated Manchester City on Monday night.