The Argentinian has endured a disastrous first season at White Hart Lane, and has made just three first team Premier League starts.
Reports suggested he was looking for a loan move back to Italy in January in order to bolster his chances of making it to the World Cup, but Tottenham refused to let a player who they forked out €30 million for last summer leave.
Now Lamela has suffered another setback after manager Tim Sherwood confirmed that he had suffered a back injury during his rehabilitation from a thigh complaint which has kept him out since Tottenham's 3-0 win over Stoke on December 29.
"Lamela had a thigh strain and he was over-compensating for that, so now he has got a problem in his back, which we are assessing and we are not too confident," Sherwood said. "It will be weeks.
According to the Guardian, the former Roma winger is likely to be sidelined for about six weeks, which puts him in line for a return in April.
Sherwood continued: "It is difficult to adapt to a different country, a different league and a different language but, when you are suffering all these niggles and something more than minor at the moment, it is disappointing for the lad.
"But we signed him for the long term and we are sure that, in the end, he will come good for Tottenham and be a crowd favourite here.
"We are all big fans of him when we see him in training. It is just difficult to adjust to a different style of play and a different language. I'm sure Erik will pick it up. By the time he is fit, he will be fluent."
Tottenham will continue their pursuit of a top four place this evening when they travel to St. James's Park to take on Newcastle.