Manchester United vs Olympiacos
First leg: February 25 at Stadio Karaiskaki
Second leg: March 19 at Old Trafford
Last season this would have been viewed as an easy encounter for Manchester United, but how times have changed since. United go into their Champions League tie after what will inevitably be a tough match against Crystal Palace at Selhurst Park.
However, United have arguably played their best football in the Champions League, after dominant performances against Shakhtar Donetsk, Real Sociedad and Bayer Leverkusen. In theory, it should be a walk in the park, but United haven't enjoyed any easy games since the turn of the year.
With Wayne Rooney and Robin van Persie still regaining match fitness, they could prove vital over the two legs, with much expectancy on Juan Mata to unlock the opposition's defence. United should have enough to defeat their Greek counterparts, especially as they sold their best player to Fulham in the January transfer window, Kostas Mitroglou.
Prediction: 3-1 to Manchester United on aggregate