Marked as the return of Didier Drogba, Chelsea will need to forget the nostalgia and focus on dominating the match, if they are to walk away from Turkey in a strong position.
Galatasaray, last year's quarter-finalists gave Jose Mourinho and his Real Madrid side a tough time last year, winning the second leg, but losing the tie overall.
And they were able to progress in this year's edition in a group which contained the Spanish giants as well as Scudetto winners Juventus.
Now up against Mourinho's Chelsea, Galatasaray boss Roberto Mancini will feel his side is capable of a first leg scalp against his adversary, despite giving his opponents an 80% chance of going through.
One man Mourinho will know about is Drogba. The legendary striker achieved hero status whilst at Chelsea, where he scored 157 goals in eight years.
The man, who effectively won the Blues the Champions League is now looking to knock them out of it.
At 36, Drogba's best days are admittedly behind him. But any Chelsea fan will tell you of the threat the Ivorian poses, having scored 12 goals this season for Galatasaray.
Also in the armoury of the Turkish giants is Wesley Sneijder. The Dutchman is another player Mourinho is familiar with, having managed him for two years whilst at Inter.
Sneijder was at his very best under the Portuguese coach and many considered him one of the world's best.
Much like Drogba, Sneijder is no longer at his peak, but the midfielder can still punish Mourinho's side with his accurate passing and dangerous set pieces.
Another who can cause Chelsea problems going forward is Burak Yilmaz. With 12 goals in 21 league appearances the Turk is another difficult customer that can cause Terry and Co. problems in defence.
Felipe Melo has to many been Gala's best player this season. Sitting at the heart of midfield, his job will no doubt be to shackle fellow Brazilian Oscar.
Whatever team Mancini chooses to name, it will no doubt be a strong one, and Chelsea cannot afford to complacent, or they'll be stung, much in the same manner as Manchester United yesterday.
Write for GiveMeSport! Sign-up to the GMS Writing Academy here: http://gms.to/1a2u3KU