The Dutchman joined the club in 2012, and helped fired them to the Premier League title in his first season.
However since then legendary boss Sir Alex Ferguson has announced his retirement and Manchester United have endured a slump under David Moyes. According to reports, Van Persie took the news of Ferguson's retirement particularly badly.
The Red Devils are currently in danger of missing out on a top four finish and suffered a shock 2-0 defeat against Olympiakos in the first leg of their last 16 Champions League tie last night.
The former Arsenal striker's injury problems this season have also exacerbated his discontent at Old Trafford, and now the Guardian claim he is considering leaving the club in the summer.
Recent reports linked him with a move back to the Gunners, although Arsenal boss Arsene Wenger wouldn't be drawn on the speculation when quizzed on the matter recently.
Van Persie seemingly hit out at Moyes after the defeat in Greece last night. Speaking on Dutch TV he claimed that his game was being affected by his team-mates moving into space that he usually occupies.
"Our fellow players are sometimes occupying the spaces I want to play in," he said.
"And when I see that it makes it difficult for me to come to those spaces as well. So that forces me to adjust my runs, based on the position of my fellow players. And unfortunately, they're often playing in my zones. I think that's a shame."