Spain manager Vicente del Bosque has dropped both Fernando Torres and Juan Mata have both been dropped for next week's friendly against Italy, with the La Roja chief choosing other options including Atletico Madrid striker Diego Costa.
Torres has paid the price for largely being overlooked by Blues boss Jose Mourinho in the Premier League, with Wednesday night's start in the Champions League against Galatasaray an increasingly rare occurrence.
Mourinho has trusted Samuel Eto'o in the big matches and as a result Del Bosque has looked elsewhere, handing Costa a chance to make his Spain debut alongside Alvaro Negredo and Pedro.
Mata's omission is slightly more surprising given his recent £37.1m move to Manchester United in search of star billing and consistent first-team football, with Del Bosque not convinced the playmaker deserves a call over Arsenal star Santi Cazorla or Manchester City maestro David Silva.
Arsenal defender Nacho Monreal also misses out on Del Bosque's 23-man squad to take on the Azzurri, with Jesus Navas and Cesar Azpilicueta completing the Premier League contingent of stars that make the cut.
There is still time for Torres, Monreal and Mata to persuade Del Bosque that they deserve a recall, but that window of opportunity is fast closing as this summer's South American showpiece looms large.
Spain squad to face Italy:
Goalkeepers: Iker Casillas (Real Madrid), Pepe Reina (Napoli, on loan from Liverpool), Victor Valdés (Barcelona)
Defenders: Juanfran (Atletico Madrid), Javi Martínez (Bayern Munich), Sergio Ramos (Real Madrid), Jordi Alba (Barcelona), Cesar Azpilicueta (Chelsea), Raul Albiol (Napoli)
Midfielders: Xabi Alonso (Real Madrid), Sergio Busquets (Barcelona), Xavi Hernandez (Barcelona), Koke (Atletico Madrid), Thiago Alcantara (Barcelona), Andres Iniesta (Barcelona), Jesus Navas (Manchester City), Santi Cazorla (Arsenal), Cesc Fabregas (Barcelona), David Silva (Manchester City)
Forwards: Diego Costa (Atletico Madrid), Alvaro Negredo (Manchester City), Pedro Rodriguez (Barcelona)