Arsenal manager Arsene Wenger will hope to celebrate his 1000th match as Gunners boss in style tomorrow afternoon against Chelsea, although given his record against Jose Mourinho that may prove a very difficult task.
Wenger has never beaten Mourinho in a competitive fixture and have a whole host of top players out through injury including Aaron Ramsey, Jack Wilshere, Mesut Ozil and Theo Walcott.
The Gunners can take heart from last week's spirited display in the North London derby, defending manfully throughout to make sure that Tomas Rosicky's early strike was decisive.
Rosicky himself is a doubt to face the Blues after taking a knock in training, but Alex Oxlade-Chamberlain is fit to feature and likely to continue in central midfield.
With options limited Wenger's selection dilemmas are limited, with Lukas Podolski's continued presence on the left wing perhaps the only contentious call.
Mourinho meanwhile will have to shuffle his pack due to a pair of suspensions in midfield, with Ramires and Willian both ineligible after red cards against Aston Villa last weekend.
Andre Schurrle will look to take Willian's place out wide, while in midfield Nemanja Matic should return alongside Frank Lampard after being forced to miss the midweek Champions League clash with Galatasaray.
In attack Samuel Eto'o will expect to continue ahead of Fernando Torres, with Mourinho trusting his veteran forward to lead the line attack in the majority of big matches this season.
Just four points separate the London pair ahead of tomorrow's blockbuster showdown, which is even more significant given Liverpool and Manchester City's close proximity to the top of the table, in a four-way title tussle that hangs in the balance heading into the business end of the campaign.
Chelsea predicted starting XI: Cech, Azpilicueta, Terry, Cahill, Ivanovic, Matic, Lampard, Schurrle, Oscar, Hazard, Eto'o
Arsenal predicted starting XI: Szczesny, Sagna, Mertesacker, Koscielny, Gibbs, Arteta, Oxlade-Chamberlain, Podolski, Cazorla, Rosicky, Giroud
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