Writing in his column for the Telegraph, Owen says Moyes got it wrong from the outset.
"It could be argued the biggest mistake David Moyes made at Manchester United was in his first week in charge," Owen writes. "That was when he decided a full regime change was required at Old Trafford rather than just a managerial one."
After taking charge at Old Trafford, Moyes decided to oust the existing set-up and bring in his own staff.
Dumped out of both of the domestic cups in embarrassing fashion, seventh in the league and set to face Bayern in Europe, Moyes' first season in charge has been disastrous.
"Had Moyes retained the loyal lieutenants who thrived alongside Sir Alex and knew the club, players and entire staff so well, I do not believe the current situation would be so critical for the new manager so soon into his reign."
Owen even goes as far as saying that Rene Meulensteen, Eric Steele and Mike Phelan leaving the club had a bigger impact than Alex Ferguson's departure.
"I was surprised when the backroom trio was asked to leave and in retrospect it upset the dynamic at the club even more than Sir Alex’s departure," he writes.
"On a day-to-day basis, he was not a hands-on manager so although United were always going to miss his wisdom, his tactical insight and his motivational presence in the changing room, in terms of the day-to-day engagement with players and staff the transition could have been handled better."
United face Aston Villa today, and Moyes will be looking to avoid yet another embarrassing result at Old Trafford.