Gregg Popovich's team, who lost to the Miami Heat in the 2013 Finals will face Alba Berlin in Germany on Ocotber 8th before travelling to Turkey to play Fenerbahçe Ülker Istanbul.
Alba Berlin have won eight German championships and will host the Spurs at the O2 World Berlin arena before the four-time NBA Champions face Fenerbahçe at the Ülker Sports Arena.
The games are part of a global series of preseason fixtures which will include the 2013 NBA champion Miami Heat facing the Cleveland Cavaliers in Brazil.
The Brooklyn Nets, who played a regular season game in London earlier this season will also join the action playing the Sacramento Kings twice in China.
New NBA Commissioner, Adam Silver heralded the fixtures as a step forward for the game's global development:
“As the passion for the game continues to grow globally we are focused on finding unique and meaningful ways to connect with fans worldwide, and the NBA Global Games are part of those efforts,” said Silver.
“Basketball brings people together across cultural and geographic lines, and these games are a great opportunity for our fans to experience the excitement of the NBA first-hand.”
In addition to the games, the NBA will also host a number of off-the-court activities as part of their NBA Cares program.
The NBA also plan to host a number of regular season games to be held overseas, the dates for these games will be released at a later date.