The situation looks very bleak for Cardiff City. Six points from safety, with five games to play.
Gaston Ramirez and Artur Boruc will have fitness test ahead of the game. One player definitely out is forward Jay Rodriguez, who ruptured a cruciate ligament which will see him miss out on the chance to go to the World Cup. He will be a big miss for Southampton, after having such an impressive season. Maya Yoshida remains out.
Cardiff winger Craig Noone has been ruled out for the rest of the season with an abdominal injury.
Kenwyne Jones, Declan John and Ben Turner and Craig Bellamy are all doubts for the Welsh side.
Ole Gunnar Solskjaer's side have conceded 20 goals in their last seven matches and they will need to tighten up a lot if they are to stop an impressive Southampton side.
Solskjaer’s team haven’t won since their 2-1 victory over Fulham in early March. They will have to stop that run in this game if they are to have any chance of staying up.
The Saints were comprehensively beaten 4-1 away at Manchester City last week, and will be looking to bounce back straight away. They currently sit 8th in the league, two points ahead of Newcastle United. Should they beat Cardiff, it will leave them six points behind Manchester United.
The last time the two sides met, Southampton cruised to a 3-0 victory on Boxing Day.
Southampton have failed to score in just five of their 33 league matches; only Liverpool (two) and Manchester City (four) have a better record. With Cardiff conceding goals aplenty, it presents a tough task for Solskjaer.
Should Cardiff lose, it will seem inevitable that they will be playing Championship football again next season.
Even without the injured Jay Rodriguez, Southampton should have too much for Cardiff and I can see them winning this comfortably.
Southampton 3-0 Cardiff
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