The 35-year-old exacted revenge on Bradley with a points victory in Las Vegas, which keeps the dream alive of the Filipino going head-to-head with WBC welterweight champion Mayweather, in what would be the biggest fight of the decade.
The two fighters are considered the best of their generation - but Mayweather's insistence on a strict blood-testing programme means the two camps have never been able to strike a deal. It's believe that a bout between the pair could earn them a combined $100m, although that figure is expected to decline the older they get.
Pacquiao is 35, while Mayweather recently turned 37, but the former says he will be ready to fight if the US champ feels confident enough to take him on.
"The line is open 24 hours, seven days a week," Pacquiao told reporters. "If he wants to fight, the fight will be on."
Mayweather is currently training for his May 3 bout against Argentina's Marcos Maidana, which will take place at the MGM Grand in Las Vegas.