Manchester City suffered an injury blow when midfielder Yaya Toure was forced off during their defeat to Premier League title rivals Liverpool on Sunday.
The Merseysiders themselves lost Daniel Sturridge to a strain and Jordan Henderson to a straight red card. The 'little horse' Chelsea lost Eden Hazard before their win at Swansea, so which players could be key to the title race due to their respective absences?
Toure is obviously a big loss for Manchester City. He is a powerhouse in midfield and partners Fernandinho admirably in what has been a very fruitful partnership this season. His dominating presence will be a big loss at this crucial stage of the campaign and he will liekly be replaced by Javi Garcia.
Vincent Kompany also had a torrid time against Liverpool, but manager Manuel Pellegrini remains adamant that he was fit. His training ground injury the day before the game did have an impact though as he left training early.
Chelsea have had slightly more luck than City so far this campaign, but have still been without key players. Hazard missed their game against Swansea on Sunday having limped off against PSG on Tuesday night.
Mourinho hopes that he will be fit for Saturday night's game against Sunderland though and the Portuguese should have no other worries ahead of the weekend.
Liverpool, though, are not so clear. The extent of striker Sturridge's injury is still not quite known, although he seemed to be clutching his hamstring upon leaving the field on Sunday. If he is out for a week or two, then Brendan Rodgers will have some re-arranging to do. A likely reshuffle could lead to a three-man attack of Philippe Coutinho, Luis Suarez and Raheem Sterling.
What is known is that the suspended Henderson will miss three games. The engine man has been a constant for Liverpool this season, putting in some stellar performances. His red card against City at Anfield leaves Rodgers again needing to plug a hole. Luckily for him, his central midfield is probably the strongest area of his squad in terms of depth and Lucas Levia should deputise.
We won't know who adapts better to these losses until the teams start playing, but Manchester City's loss of Toure seems to be the greatest, closely followed by Henderson.
However, if Hazard is out, then that would top the lot given that he has been Chelsea's top scorer in this fascinating title race.
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