The 26-year-old was forced into missing the Red Devils' Champions League showdown with Bayern Munich last week due to a calf injury.
However the Belgium international has been able to shake off the minor injury niggle in time to face the club he represented for five years until sealing a move to Manchester United in the summer.
The Premier League champions will be hoping to gain revenge on the Toffees after the Merseyside outfit defeated Manchester United 1-0 at Old Trafford back in December.
Sunday's game at Goodison Park will be particularly interesting as it will be the first time Moyes has returned to his former stomping ground since deciding to leave Everton at the end of last season.
Manchester United should go into the game fully refreshed as Moyes' side have not played since they were eliminated from the Champions League last Wednesday - while Everton will be hoping to bounce back from their surprise 3-2 home defeat against Crystal Palace.