Over the years, these two Premier League juggernauts have played out some unbelievable games - and their players have been subject to plenty of controversy.
With a fixture which many have said to be the deciding game of the title-race, this next meeting on April 27th promises to be another show-stopper.
They have met domestically, in the FA and League Cup, and the Champions League.
Now the rivalry between two clubs, separated 178 miles, has developed into as fierce as the Premier League has to offer, for a number of reasons.
After Liverpool's victory over Manchester City at Anfield, Chelsea must come to Merseyside looking to take all three points back to London if they stand a chance of lifting the Premier League title - it really doesn't get much bigger than this.
We take a look at why this contest has become what it is today - the good, the bad and even the ugly.