England international Jermain Defoe is back in the Toronto FC team this weekend after a recent injury, while the Houston Dynamo look to turn their season around, and the World Cup is on the horizon for the Seattle Sounders FC's stars.
Defoe will be involved in the Reds' clash with the New England Revolution this weekend, having been sidelined since the side's 3-0 defeat at Real Salt Lake in late March.
The former Tottenham Hotspur man fired three goals in his first three games in Major League Soccer, but will now be looking to prove his form and fitness to Roy Hodgson in a late bid to make England's World Cup squad.
Speaking ahead of this week's action the 31-year-old said:
"It's been frustrating because when you get off to a good start you just want it to continue for as long as possible."
And he was optimistic when asked about the World Cup:
"I don't feel like I need to sell myself to anyone, because I let my football do the talking. I've done that since I made my professional debut at 17-years-old."
"I'm sure the manager knows what I can do", the London-born striker added.
Defoe was also positive as he discussed his injury:
"It's football. It happens. You get little niggles, and luckily enough it wasn't anything that was too serious. It was just a case of resting and doing your rehab.
"It feels fine now. I feel 100 percent. I've worked really hard so maybe I'll come back stronger than I was before, which is important for the team."
The Englishman was one of three big-name signings made by Toronto in the close season, as he was joined by Michael Bradley and Julio Cesar.
United States star Bradley has also struggled with injury problems though, and the Reds have suffered as a result, losing three of their last four.
The trio will all be available to face the Revolution though, and with four of their next five games on home turf, Toronto will be looking to get back to winning ways.
Another team who have struggled to keep their key players fit so far this season is the Dynamo, but they welcomed back captain Brad Davis last week.
The USA international was the creator of Will Bruin's goal in Houston's 1-1 draw with the Portland Timbers, and he's now looking forward to this weekend's clash with Chivas USA.
The Dynamo are without a win in six, but their opponents haven't won in seven"
"It's a team that is struggling a bit themselves, so it's a great opportunity for us to go there and pick up three points," said Davis.
Despite the Dynamo's poor run of form, they still retain lofty ambitions, and their captain believes that games like this will be crucial to any potential success in the future.
"To be champions you need to be able to win on the road, so that's something we need to work on. It's always important to win, but we have to win on the road on a consistent basis."
Meanwhile, Seattle head coach Sigi Schmid has been discussing which of his players will be involved with Jurgen Klinsman's USA national team in Brazil this summer.
The Sounders are top of the MLS, and have three or four players who should be heading to the World Cup according to Schmid.
"Ultimately it's Jurgen's call. For sure, (Clint) Dempsey's someone who has been in that group all the time, (Brad) Evans has been in that group and (DeAndre) Yedlin's been in that group lately. They're probably the three guys from our team."
The 61-year-old also believes Chad Marshall's form makes him worthy of a call-up.
"I think Marshall's a good enough centre-back in comparison to the centre-backs in the national team, so he deserves consideration.
"Unfortunately the train is pretty far away from the station, and do you really want to change at this point? That's really Jurgen's decision", the German continued.
"Does he want to bring a new face into the group at this stage? That probably hurts Chad's chances, but in terms of quality he certainly has a right to be in the discussion."
Seattle face Philadelphia Union at CenturyLink Field on Saturday and will be buoyed by Clint Dempsey's nomination as Player of the Month for April, this week.
Elsewhere in the division this weekend, win-less Chicago Fire look to get the better of unbeaten Real Salt Lake, FC Dallas look to recover from their mauling at the hands of DC United against the New York Red Bulls, and fifth host fourth as the Columbus Crew go to Sporting Kansas City.
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