#4 Vince Young (Madden 08)
Vince Young was coming off a fantastic rookie season with the Tennessee Titans in 2006 before being asked to be the cover star of the game franchise.
Interestingly, Young was not the first athlete asked to appear on the cover of that year's game, instead LaDanian Tomlinson was the first choice but he refused (for financial reasons). Fans started petitions for Tomlinson not to appear on the cover, and they were rewarded with the fantastic season he went on to have.
Young on the other hand suffered an injury after just five games, the first time in his career (including college) that he had been injured. He never recovered the form of his rookie season.
The following year he suffered another knee injury, that saw him sidelined for the majority of the season, as he only played three games losing his place to Kerry Collins.