Champions Juventus require just one point from their clash against Cagliari to become the first team in the history of Serie A to break the 100-point barrier in a single campaign.
Last weekend’s narrow 1-0 win over Roma at the Stadio Olympico brought their tally to 99, with Antonio Conte’s men having won 32 of their 37 league matches thus far.
Cagliari can at least take solace in the fact they have avoided relegation for another year, yet are expected to be blitzed by the Old Lady at the Juventus Stadium on Sunday evening.
Torino will be praying star forward Ciro Immobile can fire them into next season’s Europa League against rivals Fiorentina.
The Italian forward, who has been linked with moves to Napoli and Borussia Dortmund in recent weeks, will be the centre of attention as Torino look to stave off the threat of Parma, AC Milan, Verona and Lazio to scoop the last European place.
It will be difficult given the impressive season Fiorentina have had, with their participation in the second tier of European football very much assured for next season.
Milan will be looking to bounce back from the racism-marred 2-1 defeat to Atalanta last weekend when they welcome Sassuolo to the San Siro stadium.
The Rossoneri require results elsewhere to go in their favour yet are widely expected to miss out on European football next year after a difficult season under coach Clarence Seedorf.
The Dutchman is expected to keep his job given his popularity at the club, but will need to invest heavily in the summer if the club is to be restored to the current crop of European superpowers.
Meanwhile, rivals Inter Milan will be looking to bow out on a high when they play away to Chievo who will prove stubborn opposition after defying relegation for the season.
It will be the last time the Nerazzuri play before a summer of rebuilding, with Patrice Evra expected to join former Manchester United team-mate Nemanja Vidic at the San Siro next season.
A cash injection is very much required if they, like their city rivals, are to bridge the gap on Juventus at the summit of the division over the next couple of years.
Rafael Benitez’s Napoli side will be another looking to challenge for the Scudetto next year, bowing out at home to the Luca Toni-inspired Verona.
The season has hardly gone swimmingly, but over in San Paolo the fans will be elated with a third-placed finish and eying a pop at the biggest prize after a summer of shrewd transfer activity.
Verona, meanwhile, have been one of the surprise packages of the division, and are guaranteed a place in the top half of the season regardless of the scoreline on Sunday evening.
Roma will be looking to add another three points to their lofty tally when they travel to Genoa, whilst Lazio look to inflict more damage on the already relegated Bologna.
Parma will host Livorno as another team vying for a Europa League place, whilst Catania will meet Atalanta in another game on the final matchday.
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