The Argentinian international joined Barcelona in 2010, and has won eight trophies with the club, including two La Liga titles and the Champions League.
The 29-year-old spent four seasons with Liverpool between 2006 and 2010, and is now being linked with a return to Anfield.
Mascherano only has a year remaining on his contract at the Camp Nou, and recent reports have suggested that Liverpool could look to secure his services once more in a cut-price €9 million deal.
Speaking after a disappointing end to the season which saw Barcelona miss out on the title to Atletico Madrid, the midfielder was non-committal when asked about his own future.
"This spells the end of an era, there have to be changes in order to rebuild a winning team," Mascherano said.
"My future is of little importance today, what's important is Barcelona. It's the end of an era the likes of which will never be seen again, everything comes to an end.
"We have to accept that this season hasn't been the best."
Liverpool are likely to target reinforcements in midfield over the summer, and have been linked with the likes of Emre Can and Southampton's Adam Lallana.
Barcelona are expected to have a major summer clear-out with anything up to seven players up for grabs - Mascherano included.