England need a miracle if they are to make the last 16 of the 2014 World Cup after a half fit Luis Suarez shone in a 2-1 win in Sao Paolo and condemned England to their second group stage defeat.
Italy have to beat both Costa Rica and Uruguay with England needing a big haul against Costa Rica to stand a chance of getting through on goal difference. However if Italy draw with either Costa Rica tomorrow or Uruguay next week England are going home.
Uruguay captain Diego Godin possibly should have been sent off after only a third of the game, when he was yellow carded for hand ball early on and warranted a second for a rough challenge, but the referee wasn't moved.
Suarez opened the scoring for the South Americans before half time, heading in a pin point cross from Edinson Cavani.
Wayne Rooney gave the Three Lions hope on 75 minutes as he scored his first ever World Cup goal.
A basic long ball from Uruguay's goalkeeper, Fernando Muslera, was flicked on by England captain Steven Gerrard which allowed Suarez in behind Gary Cahill to put away his second of the night and the tournament.
England defender Phil Jagielka said after the game: "It's a similar story to the Italy game. We played pretty well but obviously not good enough. [When Wayne Rooney scored] we had them on the back foot and maybe could have had a penalty with Daniel Sturridge. We had a couple of near chances but unfortunately weren't able to get that second goal.
On the second goal the Everton man added: "I'm very disappointed, as a defender that's the last thing you want to see."
England seemed to keep possession well but didn't do much with it and Uruguay never looked troubled and again, as was in the Italy game, the final killer ball was lacking.
Uruguay broke the deadlock six minutes before the break as Napoli striker Cavani cut in and sent the ball into the box, only for Suarez to get goal-side of Jagielka and nod past Joe Hart.
Despite being 1-0 down England made no attempt to get in behind Uruguay and trouble the backline, which included the inexperienced centre-back Jose Maria Gimenez, and looked to get more and more frustrated as the second half wore on.
Rooney equalised when Glen Johnson managed to break down the right hand side, cut past three Uruguayan players into the box and put the ball towards the Manchester United man who side-footed in from five yards.
It is Rooney's first goal at a World Cup and moved his total goal tally to 40, 5th on the all time England scorers list along side Michael Owen.
The equaliser rallied the England men and the crowd inside the Arena de Sao Paolo with the noise getting louder and louder in the hope it would surge the players forward towards an all important second goal.
However what seemed to be a perfectly tame long kick down field from Muslera was flicked on by Gerrard and the England defence was caught sleeping which opened the way for Suarez to run in and drive a shot past Hart high into the net.
Suarez, who had only just recovered from knee surgery and was probably only 70% fit, was mobbed by the entire Uruguay squad and with six minutes plus five minutes of added time left, England had it all to do.
Hodgson made his first change after 64 minutes, sending on Ross Barkley for Raheem Sterling, who had struggled to impose himself on Uruguay as he had against the Italians. Adam Lallana then came on for Danny Welbeck and Rickie Lambert in place of Jordan Henderson.
Unfortunately it was too late and England slumped to their first ever second-successive defeat in the group stage of a World Cup.
When asked about England's chances of making the knockout stages Jagielka stated: "There's a small chance I suppose but we're not exactly expecting anything like that. We've just got to go out on Tuesday night and put in a good performance against Costa Rica."
Before the World Cup England manager Roy Hodgson made it clear he was building for the Euro's in France in two years time and the World Cup in Russia in 2018, so hopefully the youth in the current squad won't be scarred too much by this experience.
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